RISTOCETIN REAGENTS
Perfecting vWD Management Excellence with Our Trusted Ristocetin Product Line
Bio/Data Corporation stands as a premier provider in the realm of in vitro diagnostics, offering a comprehensive array of essential reagents to facilitate precise and insightful laboratory analyses. Among its distinguished offerings is AggRecetin® (Ristocetin), a key component for unraveling the intricacies of platelet dynamics. Bio/Data takes pride in presenting Ristocetin in two sizes, ensuring versatility and adaptability in addressing the diverse needs of laboratories engaged in platelet function assessment. This dual-size availability underscores our commitment to providing top-tier diagnostic solutions, enhancing the precision and efficiency of Ristocetin Cofactor Activity Analysis within the diagnostic landscape.
AggRecetin® (Ristocetin) stands as a pivotal reagent integral to the field of in vitro diagnostics (IVD), particularly in the context of platelet function assessment. The utilization of AggRecetin, in conjunction with various IVD components, is imperative for the precise execution of the Ristocetin Cofactor Activity Analysis, a test conducted on Platelet Rich Plasma (PRP). This test plays a critical role in discerning the intricate dynamics of platelet adhesion, focusing on the interaction between von Willebrand Factor (vWF) and platelets.
The mechanism by which AggRecetin (Ristocetin) operates is intricately linked to its composition, primarily derived from Ristocetin A Sulfate, an enigmatic compound extracted from Nocardia lurida. In its lyophilized manifestation, AggRecetin encapsulates over 90% Ristocetin A, attesting to its exceptional purity and potency.
Within the orchestration of platelet dynamics, Ristocetin takes center stage by mediating platelet adhesion (agglutination) through binding to collagen and platelets. It induces the binding of vWF to the Gp1B Platelet Receptor, thereby providing valuable insights into the presence and integrity of the Platelet Glycoprotein (GP) Ibα-V-IX Complex and von Willebrand Factor (VWF) interaction. The Ristocetin CoFactor Activity Assay, conducted with patient Platelet Poor Plasma and fixed platelets, further refines our understanding of the complex interplay governing platelet behavior.
In the context of platelet-rich plasma, Ristocetin exhibits its prowess by causing Ristocetin Induced Platelet Aggregation (RIPA) when added in two concentrations. This phenomenon unfolds in platelet-rich plasma samples, shedding light on the delicate balance within the platelet dynamics regulated by AggRecetin.
The significance of AggRecetin (Ristocetin) extends beyond its role as a reagent. Its high concentration of Ristocetin A positions it as a key player in unraveling the mysteries surrounding platelet function. The molecular ballet facilitated by AggRecetin reveals a nuanced understanding of the complex mechanisms that govern hemostasis and coagulation.
In the diagnostic landscape, the application of AggRecetin (Ristocetin) finds relevance in various conditions such as Bernard-Soulier Syndrome, where Ristocetin CoFactor activity becomes crucial for interpretation. Understanding the implications of low Ristocetin CoFactor, normal ranges, and the broader spectrum of Ristocetin-induced platelet aggregation testing aids in the comprehensive assessment of platelet function. The Ristocetin test, its interpretation, and its association with von Willebrand Disease underscore the diagnostic value that AggRecetin brings to the forefront.
AggRecetin (Ristocetin) emerges not only as a reagent of exceptional purity but also as a gateway to deciphering the intricate web of interactions governing platelet function, contributing significantly to our comprehension of hemostatic balance and coagulation dynamics.